ATR Antibody / Anthrax toxin receptor / TEM8 | RQ6934

ATR Antibody / Anthrax toxin receptor / TEM8 | RQ6934 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB, Direct ELISA

Buffer: Lyophilized from 1X PBS with 2% Trehalose

Limitation: This TEM8 antibody is available for research use only.

Purity: Antigen affinity purified

Description: Anthrax toxin receptor 1 (ANTXR1 or also known as TEM8) is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Immunogen: Recombinant human protein (amino acids E33-D301) was used as the immunogen for the TEM8 antibody.

Storage: After reconstitution, the TEM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.