ATG4A Antibody | F54527-0.4ML

ATG4A Antibody | F54527-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: 1458CT808.66.25.69

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, FACS, IHC-P, IF

Buffer: N/A

Limitation: This ATG4A antibody is available for research use only.

Purity: Protein G affinity

Description: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Immunogen: Recombinant human protein was used as the immunogen for the ATG4A antibody.

Storage: Aliquot the ATG4A antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.