Description
ATF4 Antibody | R30614 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB
Buffer: N/A
Limitation: This ATF4 antibody is available for research use only.
Purity: Antigen affinity
Description: Activating Transcription Factor 4, also know as CREB2, belongs to the large ATF/CREB family of transcription factors which bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. Members of this family share significant sequence similarity within a leucine zipper DNA-binding motif and an adjacent basic region. Unlike CREB, which activates transcription from CRE-containing promoters, CREB2/ATF4 functions as a specific repressor of CRE-dependent transcription. The transcriptional repressor activity resides within the C-terminal leucine zipper and basic domain region of the ATF4 protein.
Immunogen: Amino acids 332-351 (QYLKDLIEEVRKARGKKRVP) were used as the immunogen for this ATF4 antibody (100% homologous in human, mouse and rat).
Storage: After reconstitution, the ATF4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
