Description
ARE Reporter – HepG2 Cell line (Nrf2 Antioxidant Pathway) | 60513 | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling/Cell Line
Application: • Monitor Nrf2 antioxidant response pathway activity.
• Screen for activators or inhibitors of the Nrf2 antioxidant response pathway.
Background: The Nrf2 antioxidant response pathway plays an important role in cellular antioxidant defense. Nrf2, a basic leucine zipper transcription factor, induces the expression of antioxidant and phase II enzymes by binding to the ARE (antioxidant response element) region of the gene promoter. Under basal conditions, Nrf2 is retained in the cytosol by binding to the cytoskeletal protein Keap1. Upon exposure to oxidative stress or other ARE activators, Nrf2 is released from Keap1 and translocates to the nucleus, where it can bind to the ARE, leading to the expression of antioxidant and phase II enzymes that protect the cell from oxidative damage.
Description: The ARE Reporter - Hep G2 cell line is designed to monitor Nrf2 antioxidant response pathway. The cell contains a firefly luciferase gene under the control of ARE (antioxidant response element) stably integrated into Hep G2 cells.
Product Type: Cell Line
Shippement Condition: -80°C
