Description
APC-Labeled Human FOLR1 Protein, His TagStar Staining | FO1-HA2H8-200tests| Gentaur Distribution US, UK & Europe
Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
Source: APC-Labeled Human FOLR1 Protein, His Tag (FO1-HA2H8) is produced via conjugation of APC to Human FOLR1 Protein, His Tag with a new generation site-specific technology under Star Staining labeling platform. Human FOLR1 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Arg 25 - Met 233 (Accession # P15328-1).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Arg 25 - Met 233.
Conjugate: APC Labeled.
Molecular Weight: 38.9 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.9 kDa.
Purity: 90%.
Buffer: PBS, 0.2% BSA, pH7.4.
Storage Conditions: -20℃, aviod light.
Shipping Conditions: RT
