Description
APC Anti-Mouse CD200 Antibody | DL22655F-2 | Gentaur US, UK & Europe Disrtribition
Synonyms: OX-2 membrane glycoprotein,OX-2, MRC
Reactivity: Mouse
Host: Rat
Application: FCM
Background: CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons) ; but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R) . The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.
Concentration: 0.2 mg/mL
Conjugation: APC
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Rat IgG2a, κ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
