Description
APC Anti-Mouse CD150 Antibody | DL21951F-3 | Gentaur US, UK & Europe Disrtribition
Synonyms: Slam,Slamf1,CD 150,Signaling lymphocytic activation molecule
Reactivity: Mouse
Host: Rat
Application: FCM
Background: CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.
Concentration: 0.2 mg/mL
Conjugation: APC
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Rat IgG2a, λ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
