APC Anti-Human CD279/PD-1 Antibody | DL22685F-4

APC Anti-Human CD279/PD-1 Antibody | DL22685F-4 | Gentaur US, UK & Europe Disrtribition

Synonyms: PDCD1,PD1,Protein PD-1,hPD-1

Reactivity: Human

Host: Mouse

Application: FCM

Background: Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Concentration: N/A

Conjugation: APC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Isotype: Mouse IgG1, κ

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.