APC Anti-Human CD22 Antibody | DL20668F-2

APC Anti-Human CD22 Antibody | DL20668F-2 | Gentaur US, UK & Europe Disrtribition

Synonyms: B-cell receptor CD22,Cd22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14,CD22,Lyb-8, Siglec2

Reactivity: Human

Host: Mouse

Application: FCM

Background: CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup) . CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.

Concentration: N/A

Conjugation: APC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Isotype: Mouse IgG1, κ

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.