Description
APC Anti-Human CD196/CCR6 Antibody | DL21846F-2 | Gentaur US, UK & Europe Disrtribition
Synonyms: CKRL3, CMKBR6, GPR29, STRL22,GPRCY4
Reactivity: Human
Host: Mouse
Application: FCM
Background: CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs) . CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
Concentration: N/A
Conjugation: APC
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Mouse IgG2b, κ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
