Description
AP-1 Reporter - HEK293 Cell Line (JNK signaling pathway) | 60405 | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling/Cell Line
Application: • Monitor the JNK signaling pathway activity and AP1-mediated activity.
• Screen for activators or inhibitors of the JNK signaling pathway.
Background: The stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) family of proteins incluces mitogen-activated protein kinases (MAPKs) that are activated by stress, inflammatory cytokines, mitogens, oncogenes, and inducers of cell differentiation and morphogenesis. Upon activation of the SAPK/JNK pathway, MAP Kinase Kinases phosphorylate and activate JNKs. The activated JNKs translocate to the nucleus where they phosphorylate and activate transcription factors such as c-Jun. cJun then binds to the activator protein-1 (AP1) response element and induces AP1 transcription.
Description: The AP-1 Reporter - HEK293 Cell Linee is designed for monitoring the activity of the JNK signaling pathway. The AP1 Reporter - HEK293 cell line contains a firefly luciferase gene under the control of AP1-responsive elements that are stably integrated into HEK293 cells.
Product Type: Cell Line
Shippement Condition: -80°C
