Description
Anti-TET2 monoclonal antibody | 25320 | Gentaur US, UK & Europe Disrtribition
Category: Epigenetics/Antibody
Application: WB (1:1000 - 1:1
200)
IP (5 µg/mg of RIPA lysate)
Background: TET2 (UniProt/Swiss-Prot entry Q6N021) is a methylcytosine dioxygenase that catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC). 5-hmC has been recently discovered in mammalian DNA and is abundant in Purkinje neurons, granule cells, embryonic stem cells, and brain tissue, especially in areas that are associated with higher cognitive function. Although its precise role has still to be shown, recent studies indicate that 5-hmC plays important roles distinct from 5-mC. Early evidence suggests that 5-hmC may represent a new pathway to demethylate DNA involving a repair mechanism converting 5-hmC to cytosine. Mutations in TET2 have been associated with myeloproliferative diseases such as essential thrombocythemia, polycythemia vera and primary myelofibrosis.
Description: Monoclonal antibody raised in mouse against the a recombinant protein containing the N-terminal 300 amino acids of human TET2 (tet oncogene family member 2).
Product Type: Antibody
Shippement Condition: -20°C or -80°C
