Anti-MBD1 polyclonal antibody | 25303

Anti-MBD1 polyclonal antibody | 25303 | Gentaur US, UK & Europe Disrtribition

Category: Epigenetics/Antibody

Application: ChIP (1.5 µg)
ELISA (1:1000)
WB (1:500)

Background: MBD1 (UniProt/Swiss-Prot entry Q9UIS9) is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC's) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription.

Description: Polyclonal antibody raised in rabbit against human MBD1 (Methyl-CpG-binding domain protein 1), using a KLH-conjugated synthetic peptide containing a sequence from the N-terminal part of the protein.

Product Type: Antibody

Shippement Condition: -20°C or -80°C