Description
Anti-LSD2 (KDM1B) polyclonal antibody | 25299 | Gentaur US, UK & Europe Disrtribition
Category: Epigenetics/Antibody
Application: ELISA (1:500)
Background: KDM1B (UniProtKB/Swiss-Prot entry Q8NB78), also known as LSD2, is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.
Description: Polyclonal antibody raised in rabbit against human KDM1B (lysine (K)-specific demethylase 1B) using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively.
Product Type: Antibody
Shippement Condition: -20°C or -80°C
