Anti-LSD1 polyclonal antibody | 25302

Anti-LSD1 polyclonal antibody | 25302 | Gentaur US, UK & Europe Disrtribition

Category: Epigenetics/Antibody

Application: ChIP/ChIP - seq (2 - 5 µg/ChIP)
ELISA (1:200 - 1:1000)
WB (1:1000)
IF (1:500)

Background: LSD1 (lysine specific demethylase 1, UniProt/Swiss-Prot entry O60341) is a component of the histone demethylase complex that uses FAD as a prosthetic goup. LSD1 may have a dual effect on gene transcription. As it demethylates the mono- and dimethylated Lys-4 of histone H3, which are associated with transcriptional activation, LSD1 can act as a repressor of gene expression. However, LSD1 is also capable of demethylating Lys-9 of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to activation of androgen receptor target genes. LSD1 therefore mediates different processes such as embryonic development, cell differentiation and proliferation, stem and cancer cell biology.

Description: Polyclonal antibody raised in rabbit against human LSD1 (Lysine-specific demethylase 1), using a KLH-conjugated synthetic peptide from the inner part of the protein

Product Type: Antibody

Shippement Condition: -20°C or -80°C