Description
Anti-Human IL15 (12B11E5) mAb, Mouse IgG1 | IL5-M542-1mg| Gentaur Distribution US, UK & Europe
Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132) . IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus (es) . This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x (L) . IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
Source: AntiN/AHuman IL15 (12B11E5) MAb, Mouse IgG1 is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which combines the variable region of a Mouse monoclonal antibody with mouse IgG1 constant domain. The mouse monoclonal antibody is produced from a hybridoma resulting from fusion of SP2/0 myeloma and BN/Alymphocytes obtained from a mouse immunized with IL15.
Molecule: IL15.
Species: Human.
Tag: Mouse IgG1 | Mouse Kappa.
Conjugate: Unconjugated.
Purity: 90%.
Charactirization: PBS, pH 7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
