Description
Anti-HDAC1 monoclonal antibody | 25286 | Gentaur US, UK & Europe Disrtribition
Category: Epigenetics/Antibody
Application: ChIP (2 µg/ChIP)
WB (1:2000)
IF (1:500)
Background: HDAC1 (UniProt/Swiss-Prot entry Q13547) catalyses the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Acetylation and deacetylation of these highly conserved lysine residues is important for the control of gene expression and HDAC activity is associated with gene repression. Histone deacetylation is established by the formation of large multiprotein complexes. HDAC1 also interacts with the retinoblastoma tumor suppressor protein and is able to deacetylate p53. Therefore, it plays an essential role in cell proliferation and differentiation and in apoptosis
Description: Monoclonal antibody raised in mouse against human HDAC1 (Histone deacetylase 1), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal region of the protein
Product Type: Antibody
Shippement Condition: -20°C or -80°C
