Description
Anti-FcGR3A (CD16A) IgG Antibody, Biotin-Labeled | 101225-2 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Antibody
Application: This product is for research use only. It is not suitable for human, diagnostic, or therapeutic use.
Background: N/A
Description: This anti-FcGR3A (CD16A) antibody is a purified, biotinylated, recombinant human monoclonal antibody which recognizes the human FcGR3A/CD16A protein. Fc Gamma Receptor IIIa (FcGRIIIA; FcγRIIIA), also known as CD16a, is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, antibody-dependent cytotoxicity, and clearance of immune complexes. FcGR3A/CD16A plays a role in the activation of natural killer (NK) cells. Clinically, it serves as a marker of certain immune cells such as neutrophils. CD16 expression has been observed at the surface of T cells in patients with chronic viral infections (such as COVID-19). It is considered a potential therapeutic target to potentiate the efficacy of therapeutic antibodies used to treat solid tumors, or as direct target in hematopoietic cancers. This antibody has been tested for specific binding to purified human FcGR3A/CD16A (BPS Bioscience #79013) in an ELISA binding assay with colorimetric detection. It does not cross-react with purified human FcGR2B/CD16B.
Product Type: Antibody
Shippement Condition: -80°C
