Anti-EZH2 monoclonal antibody | 25222

Anti-EZH2 monoclonal antibody | 25222 | Gentaur US, UK & Europe Disrtribition

Category: Epigenetics/Antibody

Application: ChIP (2.5 µg/ChIP)

Background: EZH2 (UniProt/Swiss-Prot entry Q15910) is a histone-lysine methyltransferase which methylates Lys-9 and Lys-27 of histone H3, leading to transcriptional repression. It is a member of the polycomb group (PcG) family which form multimeric protein complexes and are involved in maintaining the transcriptional repressive state of genes over successive cell generations. The EZH2 activity is dependent on the association with other components of the PRC2 complex (EED, SUZ12/JJAZ1, RBBP4 and RBBP7). EZH2 may play a role in the hematopoietic and central nervous systems. Over-expression of EZH2 is observed during advanced stages of prostate cancer and breast cancer.

Description: Monoclonal antibody raised in mouse against the central part of the human EZH2 protein (Enhancer of zeste homolog 2)

Product Type: Antibody

Shippement Condition: -20°C or -80°C