Description
Anti-CD47 Antagonist Antibody | 79065-1 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Antibody
Application: Useful as an antagonist to block CD47 signaling and binding to SIRP-α or SIRP-γ in biochemical assays.
Background: Cluster of Differentiation 47, or CD47, plays an essential role in cell growth, death, migration, and adhesion. CD47 binding to SIRP-α mediates phagocytosis by sending a "do not eat me" signal to phagocytes. CD47 proteins are often over expressed by tumor cells as a means for them to escape phagocytosis. As a result, cancerous tumor cells have the ability to proliferate and evade the immune system.
Description: Anti-CD47 recombinant human antagonist antibody recognizing the SIRP-α or SIRP-γ binding region of human CD47. This antibody has not been tested for cross-reactivity with any other species.
Product Type: Antibody
Shippement Condition: -80°C
