Anti-AML1-ETO polyclonal antibody | 25208

Anti-AML1-ETO polyclonal antibody | 25208 | Gentaur US, UK & Europe Disrtribition

Category: Epigenetics/Antibody

Application: ChIP/ChIP - seq (4 µl/ChIP)
ELISA (1:500)
WB (1:1000)

Background: The AML1 (RUNX1) (UniProtKB/Swiss-Prot entry Q01196) - ETO (RUNX1T1) (UniProtKB/Swiss-Prot entry Q06455) fusion protein arises due to a translocation between chromosome 8 and 22 (t(8;21)(q22;q22)). This translocation is one of the most frequent karyotypic abnormalities observed in acute myeloid leukaemia. It produces a chimerical gene made up of the 5'-region of AML1and the 3'-region of ETO. The chimerical protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.

Description: Polyclonal antibody raised in rabbit against the AML1-ETO fusion protein using a KLH-conjugated synthetic peptide.

Product Type: Antibody

Shippement Condition: -20°C or -80°C