Anti-5-caC polyclonal antibody | 25201

Anti-5-caC polyclonal antibody | 25201 | Gentaur US, UK & Europe Disrtribition

Category: Epigenetics/Antibody

Application: DB (1:500 - 1:1000)
IF (1:500)
DNA IP (4 µg genomic DNA/IP)

Background: The so-called 6th base, 5-hydroxymethylcytosine has been discovered in 2009. The function of this new modified base remains mostly unclear, but it is certain that the 5-hmC base is generated by enzymatic conversion of 5-methylcytosine(5-mC) into 5-hydroxymethylcytosine by the TET family of oxygenases. Early reports suggested that 5-hmC may represent an intermediate of active demethylation in a new pathway which demethylates DNA, converting 5-mC to cytosine. Recent evidence fuel the hypothesis that 5-hmC represents an intermediate, which could involve further oxidation of the hydroxymethyl group to a formyl or carboxyl group followed by either deformylation or decarboxylation. The carboxyl and formyl groups of 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC) could be enzymatically removed without excision of the base.

Description: Polyclonal antibody raised in rabbit against 5-Carboxylcytosine (5ca-CMP monophosphate) conjugated to BSA

Product Type: Antibody

Shippement Condition: -20°C or -80°C