Description
Anti-3-mC polyclonal antibody | 25200 | Gentaur US, UK & Europe Disrtribition
Category: Epigenetics/Antibody
Application: DB (1:400)
Background: 3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.
Description: Polyclonal antibody raised in rabbit against 3-methylcytosine (3-mC) conjugated to BSA.
Product Type: Antibody
Shippement Condition: -20°C or -80°C
