Androgen Receptor Antibody | F40398-0.4ML

Androgen Receptor Antibody | F40398-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: 549CT16.1.4

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, ELISA

Buffer: N/A

Limitation: This anti-Androgen Receptor antibody is available for research use only.

Purity: Purified

Description: Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor; sumoylation of AR represses AR-dependent transcription.

Immunogen: Purified His-tagged protein fragment was used to produced this monoclonal anti-Androgen Receptor antibody.

Storage: Aliquot the anti-Androgen Receptor antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.