AMSH Core Domain, His-tag | 81081

AMSH Core Domain, His-tag | 81081 | Gentaur US, UK & Europe Disrtribition

Category: Ubiquitination/Deubiquitylating Enzymes

Application: This enzyme cleaves K63-linked ubiquitin chains in vitro. Suggested Substrate: DiUbiquitin K63

Background: AMSHcore (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSHcore mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM. AMSHcore contains only the core domain of AMSH protein.

Description: Human AMSH Core Domain recombinant protein, a.a. 250-424, with His-tag, expressed in E. coli.

Product Type: Protein

Shippement Condition: -80°C