AMPK alpha 2 Antibody (PRKAA2) | F50190-0.08ML

AMPK alpha 2 Antibody (PRKAA2) | F50190-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, ELISA

Buffer: N/A

Limitation: This AMPK alpha 2 antibody is available for research use only.

Purity: Purified

Description: AMPK alpha 2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). It acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. [UniProt]

Immunogen: A portion of amino acids 476-507 from the human protein was used as the immunogen for this AMPK alpha 2 antibody.

Storage: Aliquot the AMPK alpha 2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.