Description
AMH Antibody / Anti-Muellerian Hormone | V8910-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: AMH/6713R
Host: Rabbit
Clonality: Recombinant Rabbit Monoclonal
Isotype: Rabbit IgG
Species Reactivity: Human
Application: IHC-P
Application Details: Immunohistochemistry (FFPE): 1-2ug/ml
Application Note: Optimal dilution of the Muellerian Inhibiting Factor antibody should be determined by the researcher.
Purity: Protein A/G affinity
Description: The transforming growth factor superfamily proteins are involved in embryonic development and adult tissue homeostasis. The Muellerian inhibiting factor (MIF), also called Muellerian-inhibiting substance (MIS) and Anti-Muellerian hormone (AMH), glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIF and testosterone, the presence of which result in male offspring. Absence of MIF and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIF causes regression of the Muellerian duct. MIF inhibits the growth of tumors derived from tissues of Mullerian duct origin. It can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
Immunogen: A portion of amino acids 460-560 from the human protein was used as the immunogen for the Muellerian Inhibiting Factor antibody.
Storage: Aliquot the Muellerian Inhibiting Factor antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
Localization: Secreted
