Description
Als2Cr2 Antibody / STRADB | N1046-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB
Buffer: 1X PBS, pH 7.4
Limitation: This Als2Cr2 antibody is available for research use only.
Purity: Protein A affinity chromatography
Description: Als2Cr2, also called STE20-related kinase adapter protein beta (STRAD beta) and ILPIP, is a serine/threonine protein kinase encoded by the STRADB gene, discovered as an XIAP interacting protein. It is a mediator of the XIAP/TAK1 activation of the JNK1 pathway, an apoptosis inhibition mechanism independent of XIAP inhibition of caspases. Alone, it only moderately activates JNKs, but its interaction with XIAP/TAK1 induces a much stronger activation of JNK1, protecting against Caspase 1- or Fas-induced apoptosis.
Immunogen: A recombinant protein fragment from the interior region of human Als2Cr2 was used as the immunogen for this antibody.
Storage: Aliquot the Als2Cr2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
