Description
AKT1 Antibody | F50140-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IF, FACS, ELISA
Buffer: N/A
Limitation: This anti-AKT antibody is available for research use only.
Purity: Purified
Description: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Immunogen: A portion of amino acids 49-76 from human AKT1 was used as the immunogen for this anti-AKT antibody.
Storage: Aliquot the anti-AKT antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
