Description
AIM2 Antibody | F51969-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, FACS, IF, ELISA
Buffer: N/A
Limitation: This AIM2 antibody is available for research use only.
Purity: Antigen affinity
Description: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. [UniProt]
Immunogen: A portion of amino acids 1-50 from the human protein was used as the immunogen for this AIM2 antibody.
Storage: Aliquot the AIM2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
