Description
AF647 Anti-Mouse CD45R/B220 Antibody | DL21382F-4 | Gentaur US, UK & Europe Disrtribition
Synonyms: B220
Reactivity: Mouse
Host: Rat
Application: FCM
Background: CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.
Concentration: 0.5 mg/mL
Conjugation: AF647
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Rat IgM, κ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
