Description
AF647 Anti-Mouse CD103 Antibody | DL21018F-2 | Gentaur US, UK & Europe Disrtribition
Synonyms: Integrin alpha-E,Itgae,Integrin alpha M290,CD103
Reactivity: Mouse
Host: Rat
Application: FCM
Background: CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL) . CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Concentration: N/A
Conjugation: AF647
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Rat IgG2a, κ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
