Description
AF488 Anti-Human CD86 Antibody | DL20261F-2 | Gentaur US, UK & Europe Disrtribition
Synonyms: T-lymphocyte activation antigen CD86,Cd86,Activation B7-2 antigen,Early T-cell costimulatory molecule 1,ETC-1
Reactivity: Human
Host: Mouse
Application: FCM
Background: CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.
Concentration: N/A
Conjugation: AF488
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Mouse IgG1, κ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
