Description
AF488 Anti-Human CD40 Antibody | DL20566F-4 | Gentaur US, UK & Europe Disrtribition
Synonyms: Tumor necrosis factor receptor superfamily member 5,Cd40,B-cell surface antigen CD40,Bp50,CD40L receptor,CD40,Tnfrsf5
Reactivity: Human
Host: Mouse
Application: FCM
Background: CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand) . The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
Concentration: N/A
Conjugation: AF488
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Mouse IgG2a, κ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
