Description
ACE2 Antibody / Angiotensin-Converting Enzyme 2 | V8992SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: ACE2/6788R
Host: Rabbit
Clonality: Recombinant Rabbit Monoclonal
Isotype: Rabbit IgG, kappa
Species Reactivity: Human
Application: ELISA, IHC-P
Application Details: ELISA (For coating, order BSA-free format),Immunohistochemistry (FFPE): 1-2ug/ml
Application Note: Optimal dilution of the ACE2 antibody should be determined by the researcher.
Purity: Protein A/G affinity
Description: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Immunogen: A portion of amino acids 705-805 was used as the immunogen for the ACE2 antibody.
Storage: Aliquot the ACE2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
Localization: Cell membrane, Secreted
