ABL1 Polyclonal Antibody | E-AB-60067

ABL1 Polyclonal Antibody | E-AB-60067 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Application: WB, IHC, IF

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Background: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A synthetic peptide of human ABL1 (NP_005148.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification: Affinity purification

Dilution: WB 1:500-1:2000 IHC 1:100-1:200 IF 1:50-1:200

Conjugation: Unconjugated

Calculated Molecular Weight: 122 kDa/124 kDa

Observed Molecular Weight: 139 kDa

Clonality: N/A