A-966492 | 27601-1

A-966492 | 27601-1 | Gentaur US, UK & Europe Disrtribition

Category: PARP/Inhibitors / Activators

Application: N/A

Background: A-966492 is one of the most potent PARP inhibitors. A-966492 displays excellent potency against the PARP-1 enzyme with a Ki of 1 nM and an EC50 of 1 nM in a whole cell assay. A-966492 significantly enhances the efficacy of TMZ in a dose-dependent manner. In addition, A-966492 is orally bioavailable across multiple species, crosses the blood?brain barrier, and appears to distribute into tumor tissue. A-966492 represents a promising, structurally diverse benzimidazole analogue and is being further characterized preclinically.

Description: A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.

Product Type: Inhibitor

Shippement Condition: Room temp. (continental US) or gel packs