Description
5-Lipoxygenase Antibody | R30728 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC-P
Buffer: N/A
Limitation: This 5-Lipoxygenase antibody is available for research use only.
Purity: Antigen affinity
Description: 5-Lipoxygenase is an enzyme that in humans is encoded by the ALOX5 gene. It is a member of the lipoxygenase family of enzymes which also transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. The enzyme 5-lipoxygenase catalyzes 2 reactions in the formation of leukotrienes. Human ALOX5 contains three nuclear localization sequences (NLSs) and a phosphorylation site involved in nuclear localization. Compared with age-matched competent mice, the knockout mice developed less right heart hypertrophy. Pharmacologic inhibition or gene disruption resulted in a significant decrease of beta-amyloid production and gamma-secretase levels. ALOX5 activity is short-lived, apparently in part because of an intrinsic instability of the enzyme.
Immunogen: An amino acid sequence from the C-terminus of human ALOX5 (AERNKKKQLPYYYLSPDR) was used as the immunogen for this 5-Lipoxygenase antibody.
Storage: After reconstitution, the 5-Lipoxygenase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
