Interleukin 10 (IL10) (Immunoregulation Marker) (IL10/2651R), 1mg/mL Antibody | BNUM2651-50

Interleukin 10 (IL10) (Immunoregulation Marker) (IL10/2651R), 1mg/mL Antibody | BNUM2651-50| Gentaur Distribution US, UK & Europe

Summary.: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. .

Conjugate: Purified, BSA-free.

Storage Buffer: PBS, no BSA, no azide.

Storage Temperature: 35°C to -5°C .

Application: IHC, FFPE (verified).

Stability: Stable at room temperature or 37°C (98°F) for 7 days.